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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM2
All Species:
19.39
Human Site:
S45
Identified Species:
30.48
UniProt:
P31350
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31350
NP_001025.1
389
44878
S45
S
G
T
R
V
L
A
S
K
T
A
R
R
I
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100144
351
40744
R41
L
L
R
K
S
S
R
R
F
V
I
F
P
I
Q
Dog
Lupus familis
XP_540076
394
45449
S50
S
G
T
R
V
L
A
S
K
T
A
R
R
I
F
Cat
Felis silvestris
Mouse
Mus musculus
P11157
390
45077
S45
S
S
T
R
V
L
A
S
K
A
A
R
R
I
F
Rat
Rattus norvegicus
Q4KLN6
390
45020
S45
S
S
A
R
V
L
A
S
K
A
A
R
R
I
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506085
394
45462
S49
N
I
T
R
V
L
A
S
K
T
A
R
K
I
F
Chicken
Gallus gallus
XP_419948
384
44421
T45
S
R
V
L
A
S
K
T
A
R
K
I
F
Q
E
Frog
Xenopus laevis
NP_001080772
386
44577
F48
S
K
T
A
R
K
I
F
Q
E
A
D
T
P
T
Zebra Danio
Brachydanio rerio
P79733
386
44575
A46
R
I
L
A
S
K
T
A
R
K
I
F
D
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48592
393
45096
I54
E
S
S
T
V
N
G
I
G
K
S
A
N
S
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42170
381
44271
A46
D
Q
T
K
A
A
S
A
E
E
T
N
N
E
S
Sea Urchin
Strong. purpuratus
XP_780110
412
47263
S59
P
Q
E
E
I
P
Y
S
Q
K
L
K
E
H
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q6Y657
333
38312
Q23
R
F
C
M
F
P
I
Q
Y
P
Q
I
W
E
M
Baker's Yeast
Sacchar. cerevisiae
P09938
399
46129
Y58
D
A
E
N
H
K
A
Y
L
K
S
H
Q
V
H
Red Bread Mold
Neurospora crassa
Q9C167
410
46679
E49
D
L
A
K
L
E
A
E
I
D
A
E
H
N
A
Conservation
Percent
Protein Identity:
100
N.A.
72.4
95.4
N.A.
91.2
89.7
N.A.
90.6
88.4
84
83.5
N.A.
68.9
N.A.
59.9
67.9
Protein Similarity:
100
N.A.
82
96.4
N.A.
95.3
94.6
N.A.
95.4
94
91
90.7
N.A.
79.3
N.A.
74.8
77.6
P-Site Identity:
100
N.A.
6.6
100
N.A.
86.6
80
N.A.
80
6.6
20
0
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
N.A.
13.3
100
N.A.
86.6
80
N.A.
93.3
13.3
26.6
13.3
N.A.
20
N.A.
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.8
58.4
64.3
Protein Similarity:
N.A.
N.A.
N.A.
69.9
71.4
75.8
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
14
14
7
47
14
7
14
47
7
0
0
14
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
0
0
0
0
0
0
0
0
7
0
7
7
0
0
% D
% Glu:
7
0
14
7
0
7
0
7
7
14
0
7
7
20
7
% E
% Phe:
0
7
0
0
7
0
0
7
7
0
0
14
7
0
34
% F
% Gly:
0
14
0
0
0
0
7
0
7
0
0
0
0
0
0
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
7
7
7
7
% H
% Ile:
0
14
0
0
7
0
14
7
7
0
14
14
0
40
0
% I
% Lys:
0
7
0
20
0
20
7
0
34
27
7
7
7
0
0
% K
% Leu:
7
14
7
7
7
34
0
0
7
0
7
0
0
0
7
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
7
0
0
7
0
7
0
0
0
0
0
7
14
7
0
% N
% Pro:
7
0
0
0
0
14
0
0
0
7
0
0
7
7
0
% P
% Gln:
0
14
0
0
0
0
0
7
14
0
7
0
7
7
7
% Q
% Arg:
14
7
7
34
7
0
7
7
7
7
0
34
27
0
0
% R
% Ser:
40
20
7
0
14
14
7
40
0
0
14
0
0
7
14
% S
% Thr:
0
0
40
7
0
0
7
7
0
20
7
0
7
0
7
% T
% Val:
0
0
7
0
40
0
0
0
0
7
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
0
0
7
7
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _